Coding

Part:BBa_K1328004

Designed by: Lingfeng Hou   Group: iGEM14_Tsinghua   (2014-10-09)

PDX-1

2014-PDX-1.png

PDX-1 is a transcriptional factor that activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription.

It’s essential for development of pancreas and maintain of the hormone-producing phenotype of the beta-cell.

PDX-1 is used here for glucose-dependent regulation of insulin gene expression.


PDX-1

PDX-1 is a transcription factor involved in the expression of insulin and insulin-related genes. Co-transfection of PDX-1 and MafA in mammalian cells induces cell-type conversion to insulin producing beta-cells.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal SapI.rc site found at 331
    Illegal SapI.rc site found at 664


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Categories
Parameters
None